Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2021
Forfattere
Spiridoula Athanasiadou Marit Almvik Jarkko Hellström Eva Madland Nebojsa Simic Håvard SteinshamnSammendrag
Copyright © 2021 Athanasiadou, Almvik, Hellström, Madland, Simic and Steinshamn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Forfattere
Fabian Sauter Harald Albrecht Johannes Kollmann Marion LangSammendrag
Det er ikke registrert sammendrag
Forfattere
Anastasia Georgantzopoulou Sebastian Kühr Andy Booth Julia Farkas Claire Coutris Ralf Kaegi Mark Rehkämper Ailbhe Macken Kuria Ndungu Patricia Almeida Carvalho Saer Samanipour Kevin V. Thomas Karina Petersen Tania Gomes Maria Thérése Hultman Adam David LillicrapSammendrag
The production, diversity and use of engineered nanomaterials (ENMs) increases globally as the market and number of applications for ENM expands. Silver (Ag), zinc (Zn) and titanium dioxide (TiO2) ENMs are among the most widely used in industrial processes and consumer products leading to increased releases to wastewater treatment plants (WWTP) from domestic and industrial sources. Material flow analyses suggest that landfills or agricultural soils and sediments are the main receiving compartments for ENM, depending on the application and ENM type. However, knowledge on the fate and transformation of ENMs in WWTP biosolids following their use as fertilizer on agricultural land, their impacts on soil and sediment ecosystems released through run-off after land-application are only poorly understood. ENTRANS aims to improve the understanding of the behavior and physicochemical transformation processes impacting ENM in different environmental media (wastewater, biosolids, soil, sediment) and how this transformation influences ENM bioavailability, bioaccumulation and toxicity in organisms from receiving environments considered to be the final sinks for ENMs, soil and sediments. The ENTRANS project will follow and characterize the physicochemical transformation of ENMs in WWTP and environmental compartments. Using isotopically labelled Ag, Zn and TiO2 ENMs, the transformation and further impact of these particles, including bioavailability, bioaccumulation, biodistribution and toxicity, will be tracked and studied using relevant in vitro and in vivo models to provide a better understanding of the link between transformation, uptake and observed toxicity. Existing guidelines will be improved to incorporate environmentally relevant exposures and toxicity endpoints of regulatory relevance and novel bioassays will be developed focusing on immune and stress responses. The transformation processes, exposure and uptake, biodistribution and toxicity data will be carefully generated so that the obtained results can be integrated into computational fate and exposure models and a risk assessment can be performed.
Forfattere
Theresa WeiglSammendrag
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Forfattere
Mårten WennerbergSammendrag
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Forfattere
Anne Kjersti BakkenSammendrag
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Forfattere
Fatima Heinicke Xiangfu Zhong Siri Tennebø Flåm Johannes Breidenbach Magnus Leithaug Marthe Thoresen Mæhlen Siri Lillegraven Anna-Birgitte Aga Ellen Sauar Norli Maria Dahl Mjaavatten Espen Andre Haavardsholm Manuela Zucknick Simon Rayner Benedicte Alexandra LieSammendrag
Rheumatoid arthritis (RA) is a complex disease with a wide range of underlying susceptibility factors. Recently, dysregulation of microRNAs (miRNAs) in RA have been reported in several immune cell types from blood. However, B cells have not been studied in detail yet. Given the autoimmune nature of RA with the presence of autoantibodies, CD19+ B cells are a key cell type in RA pathogenesis and alterations in CD19+ B cell subpopulations have been observed in patient blood. Therefore, we aimed to reveal the global miRNA repertoire and to analyze miRNA expression profile differences in homogenous RA patient phenotypes in blood-derived CD19+ B cells. Small RNA sequencing was performed on CD19+ B cells of newly diagnosed untreated RA patients (n=10), successfully methotrexate (MTX) treated RA patients in remission (MTX treated RA patients, n=18) and healthy controls (n=9). The majority of miRNAs was detected across all phenotypes. However, significant expression differences between MTX treated RA patients and controls were observed for 27 miRNAs, while no significant differences were seen between the newly diagnosed patients and controls. Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR-223-3p, miR-486-3p and miR-23a-3p. MiRNA target enrichment analysis, using the differentially expressed miRNAs and miRNA-target interactions from miRTarBase as input, revealed enriched target genes known to play important roles in B cell activation, differentiation and B cell receptor signaling, such as STAT3, PRDM1 and PTEN. Interestingly, many of those genes showed a high degree of correlated expression in CD19+ B cells in contrast to other immune cell types. Our results suggest important regulatory functions of miRNAs in blood-derived CD19+ B cells of MTX treated RA patients and motivate for future studies investigating the interactive mechanisms between miRNA and gene targets, as well as the possible predictive power of miRNAs for RA treatment response.
Forfattere
Matthias KoeslingSammendrag
Hvordan henger klima, kjøtt og framtiden sammen? Betyr vår kjøttkonsum noe for framtidens klima og matvareforsyning av verden befolkningen?