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Publikasjoner

NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.

NIBIO POP → NIBIO Rapport → NIBIO Bok → Våre poenggivende vitenskapelige publikasjoner →

2018

Authors

Tatsiana Espevig Agnar Kvalbein Bert Sandell

Abstract

Det er ikke registrert sammendrag

Authors

Tatsiana Espevig Karin Normann Marina Usoltseva Jo Anne Crouch Kate Entwistle

Abstract

Det er ikke registrert sammendrag

Authors

Tatsiana Espevig Trygve S. Aamlid

Abstract

http://www.sterf.org/Media/Get/2978/annual-report-2017

Authors

Bert Sandell Wendy Marie Waalen Trygve S. Aamlid Tatsiana Espevig

Abstract

Det er ikke registrert sammendrag

Authors

Tatsiana Espevig

Abstract

Det er ikke registrert sammendrag

Authors

Tatsiana Espevig

Abstract

Det er ikke registrert sammendrag

Authors

Kyrre Rickertsen Diansheng Dong Geir Wæhler Gustavsen Rodolfo M. Jr. Nayga

Abstract

Det er ikke registrert sammendrag

Authors

Sjur Spildo Prestegard

Abstract

Det er ikke registrert sammendrag

Authors

Virginie Amilien Atle Wehn Hegnes

Abstract

Det er ikke registrert sammendrag

To document

Authors

Mihaela-Olivia Dobrica Catalin Lazar Lisa Paruch Andre van Eerde Jihong Liu Clarke Catalin Tucureanu Iuliana Caras Sonya Ciulean Adrian Onu Vlad Tofan Alexandru Branzan Stephan Urban Crina Stavaru Norica Branza-Nichita

Abstract

Hepatitis B Virus (HBV) infection can be prevented by vaccination. Vaccines containing the small (S)envelope protein are currently used in universal vaccination programs and achieve protective immuneresponse in more than 90% of recipients. However, new vaccination strategies are necessary for successfulimmunization of the remaining non- or low-responders. We have previously characterized a novel HBVchimeric antigen, which combines neutralization epitopes of the S and the preS1 domain of the large (L)envelope protein (genotype D). The S/preS121–47chimera produced in mammalian cells and Nicotianabenthamiana plants, induced a significantly stronger immune response in parenterally vaccinated micethan the S protein. Here we describe the transient expression of the S/preS121–47antigen in an edibleplant, Lactuca sativa, for potential development of an oral HBV vaccine. Our study shows that oral admin-istration of adjuvant-free Lactuca sativa expressing the S/preS121–47antigen, three times, at 1lg/dose,was sufficient to trigger a humoral immune response in mice. Importantly, the elicited antibodies wereable to neutralize HBV infection in an NTCP-expressing infection system (HepG2-NTCP cell line) moreefficiently than those induced by mice fed on Lactuca sativa expressing the S protein. These results sup-port the S/preS121–47antigen as a promising candidate for future development as an edible HBV vaccine.