Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2010
Forfattere
Harald Bratli Per Magnus Jørgensen Reidar Haugan John Inge JohnsenSammendrag
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Sammendrag
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Forfattere
Bent Håvard Hellum Anita Tøsse Kathrine Høybakk Mette Thomsen Jens Rohloff Odd Georg NilsenSammendrag
Six clones of Rhodiola rosea, obtained from plants originating from widely different areas in Norway, were investigated for their in vitro inhibitory potential on CYP3A4-mediated metabolism and P-gp efflux transport activity. Presumed active constituents in the ethanol extracts of the different clones were quantified. C-DNA baculovirus expressed CYP3A4 and Caco-2 cells were used for inhibitory assays, and as positive control inhibitors ketoconazole and verapamilwere applied, respectively. A validated HPLC methodology was used to quantify the formation of 6-β-OH-testosterone and scintillation counting was used to quantify the transport of 3H-digoxin in Caco-2 cells. All clones showed potent inhibition of CYP3A4 and P-gp activities, with IC50 values ranging from 1.7 to 3.1 μg/mL and from 16.7 to 51.7 μg/ mL, respectively, being below that reported for other herbs and some known classic drug inhibitors, such as St. John’s wort and fluoxetine. Rhodiola rosea might thus be a candidate for clinically relevant drug interactions. The concentration of presumed biologically active constituents in the different clones varied considerably, but this variationwas not related to the clones’ inhibitory potential on CYP3A4 or P-gp activities. Other constituents might thus be responsible for the observed inhibitory properties. The place of origin seemed to be of minor importance for CYP3A4 or P-gp inhibition.
Sammendrag
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Forfattere
Nanna Lien Hege Henriksen Lena Lie Nymoen Marianne Wind Knut Inge KleppSammendrag
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Forfattere
Vegar Bakkestuen Per Arild Aarrestad Odd E. Stabbetorp Lars Erikstad Odd EilertsenSammendrag
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Forfattere
Louis Boumans Espen AarnesSammendrag
A copula of brightly coloured blue craneflies were photographed in Finnmark, northern Norway. The species is identified as Tipula (Beringotipula) unca Wiedemann, 1817, and the blue colour is hypothesised to result from a blatant infection with an invertebrate iridovirus (IIV). It is the first report of a naturally occurring putative IIV infection in adult craneflies.