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NIBIOs employees contribute to several hundred scientific articles and research reports every year. You can browse or search in our collection which contains references and links to these publications as well as other research and dissemination activities. The collection is continously updated with new and historical material.

2012

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Abstract

Residues of pharmaceuticals present in wastewater and sewage sludge are of concern due to their transfer to aquatic- and terrestrial food chains and possible adverse effects on non-targeted organisms. In the present work, uptake and translocation of metformin, an anti-diabetic II medicine, by edible plant species cultivated in agricultural soil has been investigated in greenhouse experiment. Metformin demonstrated a high uptake and translocation to oily seeds of rape (Brassica napus cv. Sheik and Brassica rapa cv. Valo). Expressed as an average bioconcentration factor, (BCF, plant concentration over initial concentration in soil, both in dry weight), BCF as high as 21.72 was measured. In comparison, BCFs for grains of the cereals wheat, barley and oat were in the range of 0.29 - 1.35. Uptake and translocation to fruits and vegetables of tomato (BCFs 0.02-0.06), squash (BCFs 0.12-0.18) and bean (BCF 0.88) were also low compared to rape. BCFs for carrot, potato and leaf forage Brassica napus cv. Sola were similar (BCF 1-4). Guanylurea, a known degradation product of metformin by microorganisms in activated sludge, was found in seeds from barley, beans and potatoes. The mechanisms for transport of metformin and guanidine in plants are still unknown, whereas organic cation transporters (OCTs) in mammals are known to actively transport such compounds and may guide the way for further understanding of mechanisms also in plants.