Head of Department/Head of Research
(+47) 920 10 068
Høgskoleveien 7, 1433 Ås
Academic – Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity
Kari Skjånes, Reidun Aesoy, Lars Herfindal, ...
AuthorsKari Skjånes Reidun Aesoy Lars Herfindal Hanne Skomedal
In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new therapeutics is needed is cancer therapy. As cancer therapy often cause severe side effects and loose effect due to development of drug resistance, new therapeutic agents are needed. Treating cancer by modulating the immune response using peptides has led to unprecedented responses in patients. In this review, we want to elucidate the potential for microalgae as a source of new peptides for possible use in cancer management. Among the limited studies on anti-cancer effects of peptides, positive results were found in a total of six different forms of cancer. The majority of studies have been performed with different strains of Chlorella, but effects have also been found using peptides from other species. This is also the case for peptides with immunomodulating effects and peptides with other health-promoting effects (e.g., role in cardiovascular diseases). However, the active peptide sequence has been determined in only half of the studies. In many cases, the microalga strain and the cultivation conditions used for producing the algae have not been reported. The low number of species that have been explored, as opposed to the large number of species available, is a clear indication that the potential for new discoveries is large. Additionally, the availability and cost-effectiveness of microalgae make them attractive in the search for bioactive peptides to prevent cancer.
Short communication – NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform
Yagut Allahverdiyeva, Eva-Mari Aro, Bert van Bavel, ...
AuthorsYagut Allahverdiyeva Eva-Mari Aro Bert van Bavel Carlos Escudero-Oñate Christiane Funk Jarna Heinonen Lars Herfindal Peter Lindblad Sari Makinen Merja Penttilä Kaarina Sivonen Matilde Skogen Chauton Hanne Skomedal Jorunn Skjermo
NordAqua is a multidisciplinary Nordic Center of Excellence funded by NordForsk Bioeconomy program (2017–2022). The research center promotes Blue Bioeconomy and endeavours to reform the use of natural resources in a environmentally sustainable way. In this short communication, we summarize particular outcomes of the consortium. The key research progress of NordAqua includes (1) improving of photosynthetisis, (2) developing novel photosynthetic cell factories that function in a “solar-driven direct CO2 capture to target bioproducts” mode, (3) promoting the diversity of Nordic cyanobacteria and algae as an abundant and resilient alternative for less sustainable forest biomass and for innovative production of biochemicals, and (4) improving the bio-based wastewater purification and nutrient recycling technologies to provide new tools for integrative circular economy platforms.
Lecture – Cultivation techniques for product-targeted algae biomass and screening for bioactive compounds
Kari Skjånes, Hanne Skomedal
Lecture – Microalgae cultivation for product specific biomass composition, and screening for cancer inhibitors in cold water strains
Kari Skjånes, Hanne Skomedal, Giorgia Carnovale, ...
AuthorsKari Skjånes Hanne Skomedal Giorgia Carnovale Volha Shapaval Achim Kohler Stig A. Borgvang
No abstract has been registered
Academic – Antibiotic application and resistance in swine production in China: Current situation and future perspectives
Hong Yang, Lisa Paruch, Xunji Chen, ...
AuthorsHong Yang Lisa Paruch Xunji Chen Andre van Eerde Hanne Skomedal Yanliang Wang Di Liu Jihong Liu Clarke
To meet increasing demand for animal protein, swine have been raised in large Chinese farms widely, using antibiotics as growth promoter. However, improper use of antibiotics has caused serious environmental and health risks, in particular Antimicrobial resistance (AMR). This paper reviews the consumption of antibiotics in swine production as well as AMR and the development of novel antibiotics or alternatives in China. The estimated application of antibiotics in animal production in China accounted for about 84240 tons in 2013. Overuse and abuse of antibiotics pose a great health risk to people through food-borne antibiotic residues and selection for antibiotic resistance. China unveiled a national plan to tackle antibiotic resistance in August 2016, but more support is needed for the development of new antibiotics or alternatives like plant extracts. Antibiotic resistance has been a major global challenge, so international collaboration between China and Europe is needed.
Academic – Microalgal Bioactive Compounds Including Protein, Peptides, and Pigments: Applications, Opportunities, and Challenges During Biorefinery Processes
Maria Hayes, Leen Bastiaens, Luisa Gouveia, ...
AuthorsMaria Hayes Leen Bastiaens Luisa Gouveia Spyros Gkelis Hanne Skomedal Kari Skjånes Patrick Murray Marco García-Vaquero Muge Isleten Hosoglu John Dodd Despoina Konstantinou Ivo Safarik Graziella Chini Zittelli Vytas Rimkus Victόria del Pino Koenraad Muylaert Christine Edwards Morten Laake Joana Gabriela Laranjeira da Silva Hugo Pereira Joana Abelho
No abstract has been registered
Academic – A novel chimeric Hepatitis B virus S/preS1 antigen produced in mammalian and plant cells elicits stronger humoral and cellular immune response than the standard vaccine-constituent, S protein
Mihaela-Olivia Dobrica, Catalin Lazar, Lisa Paruch, ...
AuthorsMihaela-Olivia Dobrica Catalin Lazar Lisa Paruch Hanne Skomedal Hege Særvold Steen Sissel Haugslien Catalin Tucureanu Iuliana Caras Adrian Onu Sonya Ciulean Alexandru Branzan Jihong Liu Clarke Crina Stavaru Norica Branza-Nichita
Chronic Hepatitis B Virus (HBV) infection leads to severe liver pathogenesis associated with significant morbidity and mortality. As no curable medication is yet available, vaccination remains the most costeffective approach to limit HBV spreading and control the infection. Although safe and efficient, the standard vaccine based on production of the small (S) envelope protein in yeast fails to elicit an effective immune response in about 10% of vaccinated individuals, which are at risk of infection. One strategy to address this issue is the development of more immunogenic antigens. Here we describe a novel HBV antigen obtained by combining relevant immunogenic determinants of S and large (L) envelope proteins. Our approach was based on the insertion of residues 21-47 of the preS1 domain of the L protein (nomenclature according to genotype D), involved in virus attachment to hepatocytes, within the external antigenic loop of S. The resulting S/preS121-47 chimera was successfully produced in HEK293T and Nicotiana benthamiana plants, as a more economical recombinant protein production platform. Comparative biochemical, functional and electron microscopy analysis indicated assembly of the novel antigen into subviral particles in mammalian and plant cells. Importantly, these particles preserve both S- and preS1-specific epitopes and elicit significantly stronger humoral and cellular immune responses than the S protein, in both expression systems used. Our data promote this antigen as a promising vaccine candidate to overcome poor responsiveness to the conventional, S protein-based, HBV vaccine.
Academic – Microalgal proteins for feed, food and health
M. Hayes, Hanne Skomedal, Kari Skjånes, ...
AuthorsM. Hayes Hanne Skomedal Kari Skjånes H. Mazur-Marzec A. Torunska-Sitarz M. Catala M. Isleten Hosoglu M. García-Vaquero
No abstract has been registered
Lecture – Development of a cost effective Romania-Norway joint plant-based technology platform for production of vaccines against human hepatitis viruses B (HBV) and C (HCV)
Jihong Liu Clarke, Hanne Skomedal, Lisa Paruch
Poster – Expression of envelope domain III (EDIII) based dengue antigens in tobacco chloroplasts and their molecular analyses
Jihong Liu Clarke, Johanna Gottschamel, Hege Særvold Steen, ...
AuthorsJihong Liu Clarke Johanna Gottschamel Hege Særvold Steen Sissel Haugslien Hanne Skomedal Andreas G. Lössl Stephanie Ruf Ralph Bock
No abstract has been registered
SmartVac - Next Generation Viral Hepatitis B and C vaccine development in plantsand algae using advanced biotechnological tools
Hepatitis B (HBV) and C viruses (HCV) infect the human liver, triggering persistent inflammation and eventually cirrhosis and hepatocellular carcinoma (HCC), the second leading cause of cancer-related mortality worldwide. Currently, more than 500 million people are chronically infected with HBV or HCV and at high risk of developing end stage liver disease and HCC.
Division of Food Production and Society
Risk management of imported plants and seeds: possibilities for improved pest detection to prevent the introduction and spread of new pests
Plant pathogens and invertebrates harmful to plants continue to threatenfood security and natural habitats. In Norway, the responsibility of performingplant health inspections on imported plants has gradually shifted to importersof plants who are currently responsible for internal pest control and mustbe registered with the Norwegian Food Safety Authority.